non gadolinium mri contrast agents 2020

Studies have shown that trace amounts of the toxic gadolinium ions may remain in the body following repeated GBCA administration. In: Dolphin D (ed) The Porphyrins, vol IVA. Gadolinium-based contrast agents increase diagnostic performance for detection of recurrent soft-tissue sarcoma. The structures vary and some are ionic and some are not. As a general rule, clinicians should avoid gadolinium contrast in pregnant patients, patients with severe renal disease, and patients who have an allergy to gadolinium. Marlborough, US – November 24, 2020 – GE Healthcare has received U.S. FDA approval of its macrocyclic gadolinium-based MRI contrast agent, Clariscan (gadoterate meglumine), in pre-filled syringes. U. S. Government Printing Office, Washington, D.C. Holbrook DJ, Washington ME, Leake HB, Brubaker PE (1975) Environ Health Perspect 10:95–101, Misselwitz B, Mühler A, Weinmann H-J (1995) Invest Radiol 30:611–620, Martin RB (1986) Bioinorganic chemistry of metal ion toxicity. Weinreb cited one investigation that detected elevated rates of GBCA exposure during the initial weeks of pregnancy compared with subsequent weeks. "If a patient has vague neurological complaints, which are suggestive of a chronic disease like [multiple sclerosis (MS)], one would want to administer contrast during the diagnostic MRI to fulfill the diagnostic criteria to actually make the diagnosis of MS," Huang said. receive this agent. "These findings were extremely encouraging and suggest we may be able to avoid contrast [GBCA] in the majority of MS patients undergoing routine surveillance of disease activity," she said. This novel agent, based on the essential nutrient manganese, has strong potential as a safer alternative to currently used contrast agents December 28, 2020 — Adding a contrast-enhancing agent to magnetic resonance imaging (MRI) significantly improves image quality and allows radiologists who interpret MRI scans to pick up subtle Free Gd+3 is toxic, but the chelation makes the products safe while maintaining the imaging characteristics. Karen Calechman didn’t know about the potential health risks of MRIs with a contrast agent – a dye – either when she reported for her breast MRI. Although these techniques are currently used in clinical practice, there is still a need for higher reader sensitivity and enhanced contrast on images. Abnormal tissue may enhance more than surrounding normal tissue following intravenous gadolinium. "It is based on balanced, steady-state acquisition," Huang explained. HA samples crosslinked with divinyl sulfone (DVS) have also been investigated. This is a preview of subscription content, Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Chem Rev 99:2293–2352, Bau M, Dulski P (1996) Earth Planet Sci Lett 143:245–255, Kümmerer K, Helmers E (2000) Environ Sci Technol 34:573–577, Lester CC, Bryant RG (1992) Magn Reson Med 24:236–242, Rinck PA (1993) Magnetic Resonance in Medicine. "I think that the question of gadolinium really has to be taken in the context of the diagnostic question that is being asked and how the images will change the management of the patient," Huang said. In: Sigel H (ed) Concepts on Metal Ion Toxicity (Metal Ions in Biological Systems), vol 20. Linear GBCAs are … Abnormal tissue may also retain gadolinium … Side effects include nephrogenic systemic fibrosis (NSF) which is associated with the administration of intravenous gadolinium. Debate flares over use of GBCAs and lawsuit risk, Caution indicated with new GBCAs for kidney patients, Gadolinium levels increase sharply in Tokyo rivers, Contrast not needed for follow-up MRI on MS patients, Research road map drives inquiry into gadolinium's effects, A new tool for enhanced ultrasound visualization and measurements. pp 165-199 | The amount of gadolinium found in rivers around Tokyo has risen sharply over the last two decades, in line with a rapid proliferation of MRI scanners... Clinicians should be able to avoid the use of gadolinium-based contrast agents on follow-up MRI brain scans to accurately monitor disease progression... What's causing gadolinium retention after the use of gadolinium-based contrast agents for MRI scans? Marlborough, US – December 10, 2020 ... Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. Not affiliated Plenum, New York p 89–132, Aschner M, Aschner JL (1991) Neurosci Biobehav Rev 15:333–340, Brurok H, Schjøtt J, Berg K, Karlsson JOG, Jynge P (1995) Invest Radiol 30:159–167, Brurok H, Schjøtt J, Berg K, Karlsson JOG, Jynge P (1997) Invest Radiol 32:205–211, Luckey TD, Venugopal B (1977) Metal Toxicity in Mammals. Kean noted that radiologists may consider options in the future such as deep learning as a strategy to enable decreased gadolinium dose for contrast-enhanced brain MRI, as well as possible alternatives to gadolinium such as ferumoxytol. Gadolinium-based contrast agents (GBCAs) have provided much needed image enhancement in magnetic resonance imaging (MRI) important in advancement of disease diagnosis and treatment. Focusing on MR contrast in the pediatric setting, Keen cited a 2017 survey of clinicians based at pediatric hospitals in which 87% of respondents who were radiologists were aware of the phenomenon of gadolinium deposition in the brain. interplay between GAGs and contrast agents for Magnetic Resonance Imaging (MRI) have been explored. John Wiley and Sons, New York, Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Fauci AS (1987). Cardiac MRI is a well-established tool for heart imaging. Radiologists are being particularly vigilant with respect to steering clear of gadolinium when imaging patients who are pregnant, as the safety of GBCAs in pregnancy has not been established, noted Dr. Jeffrey Weinreb of Yale University. Marcel Dekker, New York p 21–65, Keen CL, Lönnerdal B, Hurley LS (1984) Manganese. Alternatives to GBCAs are emerging such as arterial spin labeling and time-of-flight MR angiography. McGraw-Hill Books, New York, Hotta K, Tamagaki S, Suzuki Y, Tagaki W (1981) Chem L ett 6:789–790, Tamagaki S, Suzuki K, Tagaki W (1989) B ull Chem Soc Jpn 62:148–152, Sadler NP, Chuang C-C, Milburn RM (1995) Inorg Chem 34:402–404, Krishna CM, Liebmann JE, Kaufman D, DeGraff W, Hahn SM, McMurry T, Mitchell JB, Russo A (1992) Arch Biochem Biophys 294:98–106, Frost AE, Freedman HH, Westerback SJ, Martell AE (1958) J Am Chem Soc 80:530–536, Patch MG, Simolo KP, Carrano CJ (1982) Inorg Chem 21:2972–2977, Madsen SL, Bannochie CJ, Martell AE, Mathias CJ, Welch MJ (1990) J Nucl Med 31:1662–1668, Hoener B-A, Engelstad BL, Ramos EC, Macapinlac HA, Price DC, Johnson TR, White DL (1991) Journal of Magnetic Resonance Imaging 1:357–362, Liu G-C, Wang Y-M, Jaw T-S, Chen H-M, Sheu R-S (1993) J Formosan Med Assoc 92:359–366, Larsen SK, Jenkins BG, Memon NG, Lauffer RB (1990) Inorg Chem 29:1147–1152, Stark DD, Elizondo G, Fretz CJ (1990) Invest Radiol 25:S58, Shtern F, Garrido L, Compton C, Swiniarski JK, Lauffer RB, Brady TJ (1991) Radiology 178:83–89, Jenkins BG, Armstrong E, Lauffer RB (1991) Magn Reson Med 17:164–178, Sheu R-S, Liu G-C, Wang Y-M, Jaw T-S, Chen H-M, Kuo Y-T (1997) Kaohsiung J Med Sci 13:75–85, Martell AE (1981) The design and synthesis of chelating agents. GBCAs are classified as either linear or macrocyclic based on the type of ligand used. As concerns about the safety of gadolinium-based MRI contrast persist, radiologists should know that they have a number of alternatives to gadolinium, according to presentations on August 9 at the Society for MR Radiographers & Technologists (SMRT) virtual meeting. Because of its widespread use, gadolinium — which is able to sneak through wastewater treatment plants — is increasingly showing up in watersheds in and around large metropolitan areas. This service is more advanced with JavaScript available, Contrast Agents I October 29, 2020 — Contrast agents used to improve views of the heart on magnetic resonance imaging (MRI) carry a very low risk of allergic reactions, vomiting and other acute adverse events, according to a large study from Europe published in Radiology: Cardiothoracic Imaging. "When gadolinium can be minimized is in the routine follow-up of established chronic disease.". Still another novel noncontrast method is quiescent-interval single-shot (QISS) imaging, which has been found to supply strong diagnostic performance. In her SMRT 2020 talk, Huang offered a review of the state of the literature on gadolinium safety, as well as alternatives for its use. Over 10 million scientific documents at your fingertips. Gadolinium MRI Lawsuit 2020. In: Gregoriadis G (ed) Liposome Technology Entrapment of Drugs and Other Materials, vol II. If you like this content, please share it with a colleague! A retrospective review of 158 792 scans with gadolinium-based contrast agents registered in the U.S. Food and Drug Administration and drug manufacturers’ reporting system revealed 94 acute reactions related to the contrast agent (5.9 per 10 000 injections). Huang drew a parallel between the move toward more discriminating use of gadolinium as a contrast agent and the issue of decreasing radiation dose in CT. She also stressed that each decision to use gadolinium contrast should be based on the risk versus the benefit for the clinical question at hand. In: Dolphin D (ed) The Porphyrins, vol I A. In: Frieden E (ed) Biochemistry of the Essential Ultratrace Elements. Referencing the 2018 National Institutes of Health/American College of Radiology/RSNA Workshop, Weinreb put forth that the jury is still out with respect to the clinical implications of chronic gadolinium retention. A gadolinium-based contrast agent could be used for initial assessment, but it can then be used intermittently for monitoring a chronic condition, according to Huang. Cite as. © 2020 Springer Nature Switzerland AG. 14:30 Non-Gadolinium based contrast agents D. Longo, Rome/IT 14:40 GBCAs reduction: the REDUCE study A. Nederveen, Amsterdam/NL, C. Lavini, Amsterdam/NL 14:50 CNS MRI T. Granberg, Stockholm/SE 15:00 MSK MRI J.C. Vilanova, Girona/ES 15:10 Q&A 15:20 Abdominal MRI M. Ramalho, Almada/PT 15:30 Cardiovascular MRI T. Leiner, Utrecht/NL 15:40 GBCAs overuse O. Clement, Paris/FR 15:50 Q&A. Download preview PDF. Radiology 2020 ;294:117–126. The new agent, Mn-PyC3A, can overcome the disadvantages associated with gadolinium like its retention in the bone, brain, etc in normal patients and nephrogenic systemic fibrosis in renal patients. The only class of contrast agents approved for use with MRI in the U.S. is based on the heavy metal gadolinium, which is typically excreted through a patient's urine after an MRI is completed. Copyright © 2020 AuntMinnie.com. 25 Dec, 2020 , Researchers have been able to develop a contrast-enhancing agent based on manganese that has magnetic properties similar to those of gadolinium used presently. Blackwell Scientific, Oxford, Bogdanov AA, Lewin M, Weissleder R (1999) Adv Drug Delivery Rev 37:279–293, Lauffer RB (1990) Magnetic Resonance Quarterly 6:65–84, White DL (1991) Magn Reson Med 22:309–312, Richardson N, Davies JA, Radüchel B (1999) Polyhedron 18:2457–2482, Bonnemain B (1998) J Drug Targeting 6:167–174, Kuppusamy P, Wang P, Shankar RA, Ma L, Trimble CE, Hsia CJC, Zweier JL (1998) Magn Reson Med 40:806–811, Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS, Jr, Wishnia A (1994) Nature 370:199–201, Brown JJ (1996) Magnetic Resonance Imaging Clinics of North America 4:25–35, Lauterbur PC, Mendonça-Dias HM, Rudin AM (1978) Augmentation of tissue water proton spin-lattice relaxation by in vivo addition of paramagnetic ions. Gadolinium contrast agents help improve the quality of MRI scans. In the 3+ oxidation state the metal has seven unpaired electrons. Part of Springer Nature. While there are still questions that need to be answered about gadolinium, it can't hurt to find ways to reduce its use, especially in certain patient populations, according to Dr. Susie Huang, PhD, of Massachusetts General Hospital and Harvard Medical School in Boston. Two manganese(II)-based agents, the liver-specific agent manganese(II)-dipyridoxal diphosphate (Teslascan®) and an oral agent containing manganese(II) chloride (Lumen Hance®), and one ferric ammonium citrate-containing oral agent (FerriSeltz®) are available clinically for human use. All Rights Reserved. Dec 15 2020 Adding a contrast-enhancing agent to magnetic resonance imaging (MRI) significantly improves image … 207.180.211.132. The paramagnetic properties of ionized gadolinium have facilitated these advancements, but ionized gadolinium carries toxicity risk. "The absence of evidence is not evidence of absence," he said. PurposeTo determine the diagnostic efficacy of gadolinium-based contrast agents for the detection of recurrent soft-tissue sarcoma compared with non–contrast-enhanced conventional MRI … T But Huang noted that time-of-flight MR angiography does not have good yield for imaging tortuous/oblique vessels where the flow is not perpendicular to the imaging plane, in patients who are motion prone due to long acquisition times, or in the presence of slow or turbulent flow for signal loss can occur, which can be confounded as potential stenosis or even occlusion. Concerns around gadolinium-based contrast agents (GBCAs) include both gadolinium deposition disease, a controversial term that refers to the retention of small amounts of gadolinium in the body long after MRI scans take place, and nephrogenic systemic fibrosis (NSF), a debilitating disease that occurs in individuals with compromised kidney function. The majority of cardiac MRI exams use intravenous gadolinium-based contrast agents (GBCAs) to improve visualization of … Although the intrinsic properties of these metal ions tend to make these agents less attractive than gadolinium(III)-based agents, the large volume of literature on the biochemistry of … GBCAs were formulated with organic chelates designed to … The majority of cardiac MRI exams use intravenous gadolinium-based contrast agents (GBCAs) to improve visualization of the heart muscle and blood flow. "One might argue that in cases where you are trying to detect lesions that will actually change the patient's treatment course, say in the staging of cancer, the detection of metastases may very well determine whether a patient is able to get surgery or should undergo more systemic treatment such as chemotherapy.". All MRI contrast agents contain gadolinium (Gd+3) bound to a chelating agent. Pointing to data from a study published last year in Radiology in which investigators concluded that the use of a GBCA at follow-up MRI did not modify the diagnosis of interval disease progression in patients with MS, Huang described the results as evidence for more restrictive use of GBCAs. Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Calculated from NIOSH (1982) Registry of the Toxic Effects of Chemical Substances. "Early studies have shown it to be effective for evaluating peripheral arterial disease at 1.5 and 3T.". Gadolinium is used in magnetic resonance imaging as an MRI contrast agent. Not logged in Many patients who have received a gadolinium contrast agent during an MRI filed a lawsuit after the long-term effects of this substance devastated their bodies. In: Martell AE, Anderson WF, Badman DG (eds) Development of Iron Chelators for Clinical Use. Elsevier/North Holland, New York p 13–31, Cotton FA, Wilkinson G, Murillo CA, Bochmann M (1999) Advanced Inorganic Chemistry. At least one-third of MRI (Magnetic Resonance Imaging) scans are performed with a contrast agent known as Gadolinium to enhance the quality of the image. Kean is a radiologic technologist at Royal Children's Hospital Melbourne, Murdoch Children's Research Institute, Melbourne, Australia. While GBCM-enhanced MRI examinations are preferred over unenhanced examinations for many indications, they may be delayed or denied in patients with impaired kidney … Researchers have … Academic, New York, pp 752–759, Chen C-W, Cohen JS, Myers CE, Sohn M (1984) FEBS Lett 168:70–74, Kreft BP, Baba Y, Tanimoto A, Finn JP, Stark DD (1993) Radiology 186:543–548, Elizondo G, Fretz CJ, Stark DD, Rocklage SM, Quay SC, Worah D, Tsang Y-M, Chen MCM, Ferrucci JT (1991) Radiology 178:73–78. Contrast agents for magnetic resonance imaging based on metal ions other than gadolinium(III) including manganese(II), manganese(III), iron(III) and copper(II), have been investigated over the past decade. Pediatric patients may represent another population, along with patients with chronic disease, who should be spared frequent exposure to GBCAs, Huang said. "One study showed higher rates [of gadolinium contrast use] in the first two weeks of pregnancy, probably because the patients did not know they were pregnant," Weinreb said. Patients who refuse the use of a contrast agent and/or have concern about gadolinium deposition are also not suitable candidates for gadolinium. In addition to agents designed for use in living systems, contrast agents that measure pH and redox reactions in non-living systems have also been investigated and will be discussed. Contrast agents used to improve views of the heart on MRI carry a very low risk of allergic reactions, vomiting and other acute adverse events, according to a large new study. Academic, New York p 389–483, Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J, Peng Q (1998) J Natl Cancer Inst 90:889–905, Musser DA, Fiel RJ (1991) Photochem Photobiol 53:119–123, Koenig SH, Brown RD, Spiller M (1987) Magn Reson Med 4:252–260, van Zijl PCM, Place DA, Cohen JS, Faustino PJ, Lyon RC, Patronas NJ (1990) Acta Radiol Suppl 374:75–79, Yushmanov VE, Tominaga TT, Borissevitch IE, Imasato H, Tabak M (1996) Magn Reson Imaging 14:255–261, Fiel RJ, Button TM, Gilani S, Mark EH, Musser DA, Henkelman RM, Bronskill MJ, van Heteren JG (1987) Magn Reson Imaging 5:149–156, Lyon RC, Faustino PJ, Cohen JS, Katz A, Mornex F, Colcher D, Baglin C, Koenig SH, Hambright P (1987) Magn Reson Med 4:24–33, Place DA, Faustino PJ, van Zijl PCM, Chesnick A, Cohen JS (1990) Invest Radiol 25:S69–S70, Place DA, Faustino PJ, Berghmans KK, van Zijl PCM, Chesnick AS, Cohen JS (1992) Magn Reson Imaging 10:919–928, Bockhorst K, Höhn-Berlage M, Kocher M, Hossmann K-A (1990) Magn Reson Imaging 8:499–504, Bockhorst K, Höhn-Berlage M, Ernestus R-I, Tolxdorff T, Hossmann K-A (1993) Magn Reson Imaging 11:655–663, Ni Y, Petré C, Miao Y, Yu J, Cresens E, Adriaens P, Bosmans H, Semmler W, Baert AL, Marchal G (1997) Invest Radiol 32:770–779, Mäurer J, Strauss A, Ebert W, Bauer H, Felix R (2000) Melanoma Res 10:40–46, Ernestus R-I, Wilmes LJ, Hoehn-Berlage M (1992) Clin Exp Metastasis 10:345–350, Wilmes LJ, Hoehn-Berlage M, Els T, Bockhorst K, Eis M, Bonnekoh P, Hossmann K-A (1993) Journal of Magnetic Resonance Imaging 3:5–12, Hoehn-Berlage M, Bockhorst K (1994) Technology and Health Care 2:247–254, Ikezaki K, Nomura T, Takahashi M, Zieroth BF, Fukui M (1994) Acta Neurochir Suppl 60:353–355, Ikezaki K, Nomura T, Takahashi M, Fritz-Zieroth B, Inamura T, Fukui M (1994) Neurol Res 16:393–397, Schmiedl UP, Nelson JA, Starr FL, Schmidt R (1992) Invest Radiol 27:536–542, Fiel RJ, Musser DA, Mark EH, Mazurchuk R, Alletto JJ (1990) Magn Reson Imaging 8:255–259, Schmiedl UP, Nelson JA, Robinson DH, Michalson A, Starr F, Frenzel T, Ebert W, Schuhmann-Giampieri G (1993) Invest Radiol 28:925–932, Schuhmann-Giampieri G, Schmitt-Willich H, Press W-R, Negishi C, Weinmann H-J, Speck U (1992) Radiology 183:59–64, Vittadini G, Felder E, Tirone P, Lorusso V (1988) Invest Radiol 23:S246–S248, Nelson JA, Schmiedl U, Shankland EG (1990) Invest Radiol 25:S71–S73, Robinson DH, Schmiedl UP, Starr FL, Nelson JA, Malek R (1995) Academic Radiology 2:43–49, Schmiedl UP, Nelson JA, Teng L, Starr F, Malek R, Ho RJY (1995) Academic Radiology 2:994–1001, von Ingersleben G, Schmiedl UP, Dong P, Nelson JA, Starr F, Ho RJY (1997) Academic Radiology 4:355–360, Dong P, Choi P, Schmiedl UP, Nelson JA, Starr FL, Ho RJY (1995) Biochemistry 34:3416–3422, Liu T, Bui T, Schmiedl UP, Ho RJY (1999) Invest Radiol 34:615–620, Fawwaz RA, Winchell HS, Frye F, Hemphill W, Lawrence JH (1969) J Nucl Med 10:581–585, Fawwaz RA, Hemphill W, Winchell HS (1971) J Nucl Med 12:231–236, Bohdiewicz PJ, Lavallee DK, Fawwaz RA, Newhouse JH, Oluwole SF, Alderson PO (1990) Invest Radiol 25:765–770, Fawwaz R, Bohdiewicz P, Lavallee D, Wang T, Oluwole S, Newhouse J, Alderson P (1990) Int J Radiat Appl Instrum Part B 17:65–72, Ni Y, Marchal G, Yu J, Lukito G, Petré C, Wevers M, Baert AL, Ebert W, Hilger C-S, Maier FK, Semmler W (1995) Academic Radiology 2:687–699, Marchal G, Ni Y, Herijgers P, Flameng W, Petré C, Bosmans H, Yu J, Ebert W, Hilger C-S, Pfefferer D, Semmler W, Baert AL (1996) European Radiology 6:2–8, Fujimori H, Matsumura A, Yamamoto T, Shibata Y, Yoshizawa T, Nakagawa K, Yoshii Y, Nose T, Sakata I, Nakajima S (1997) Acta Neurochir 70:167–169, Yamamoto T (1999) Neurosurgery 44:1149–1150, Matsumura A, Shibata Y, Yamamoto T, Nakagawa K, Yasuda S, Nakajima S, Sakata I, Yoshizawa T, Nose T (1997) N eurologia Medico-Chirurgica 37:327–331, Yamamoto T, Matsumura A, Shibata Y, Fujimori H, Nakai K, Yoshida F, Nose T, Sakata I, Nakajima S, Miwa N (1998) Neurosurgery 42:1332–1338, Ni Y, Miao Y, Semmler W, Marchal G (1999) Neurosurgery 44:1146–1149, Hill JS, Kahl SB, Kaye AH, Stylli SS, Koo M-S, Gonzales MF, Vardaxis NJ, Johnson CI (1992) Proc Natl Acad Sci USA 89:1785–1789, Huang LR, Straubinger RM, Kahl SB, Koo M-S, Alletto JJ, Mazurchuk R, Chau RI, Thamer SL, Fiel RJ (1993) Journal of Magnetic Resonance Imaging 3:351–356, Zhou R, Balasubramanian SV, Kahl SB, Straubinger RM (1999) J Pharm Sci 88:912–917, McMillan JH, Cox GC, Kimler BF, Spicer JS, Batnitzky S (1991) Magn Reson Imaging 9:553–558, Saini SK, Jena A, Dey J, Sharma AK, Singh R (1995) Magn Reson Imaging 13:985–990, Suzuki T, Nakano K, Tomiyoshi K, Sakata I, Endo K, Yamanaka H (1996) J Urol 156:1850–1852, Kobayashi M, Tajiri H, Hayashi T, Kuroki M, Sakata I (1999) Canc er Lett 137:83–89, Nakajima S, Shigemi N, Murakami N, Aburano T, Sakata I, Maruyama I, Inoue M, Takemura T (1997) Anti-Cancer Drugs 8:386–390, Neiland JB (1981) Microbial iron transport compounds (siderophores) as chelating agents. Gadolinium-Based Contrast Agents (GBCA) are intravenous drugs used in diagnostic imaging procedures to enhance the quality of magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA). Currently, gadolinium-based contrast agents (GBCAs) are used for this purpose, but recently concerns have been raised about the long-term safety of the gadolinium … known as gadolinium-based contrast agents or GBCAs) are injected annually, and that since 1988 more than 500 million doses have been administered worldwide, comprising approximately one-third of MRI examina-tions (1,2). Gadolinium-based MRI contrast agent for the detection of tyrosinase H. Seo and H. A. Clark, Analyst , 2020, 145 , 1169 DOI: 10.1039/C9AN02213A Gadolinium is the most common contrast agent used for MRI – it can be given intravenously or injected directly into a body part. Gadolinium(III) containing MRI contrast agents (often termed simply "gado" or "gad") are the most commonly used for enhancement of vessels in MR angiography or for brain tumor enhancement associated with the degradation of the blood–brain barrier.For large vessels such as the aorta and its branches, the gadolinium(III) dose can be as low as 0.1 mmol per kg body mass. Agents specific for tissues such as the liver, pancreas, adrenals, cancerous tumors, and even the insides of cells and neuronal tracts as well as non-specific agents have been developed and tested in animal models. Although the intrinsic properties of these metal ions tend to make these agents less attractive than gadolinium(III)-based agents, the large volume of literature on the biochemistry of these metal ions has allowed for the development of viable contrast agents. Doctors think that the risk of NSF with the other four agents is lower, but the risks of developing NSF after having received any of these four gadolinium based MR contrast agents is unclear and may well UT MRI CENTER 6431 Fannin G-605 Houston, TX … Adding a contrast-enhancing agent to magnetic resonance imaging (MRI) significantly improves image quality and allows radiologists who interpret MRI scans to … Elsevier/North-Holland, New York p 67–104, Worah D, Berger AE, Burnett KR, Cockrill HH, Kanal E, Kendall C, Leese PT, Lyons KP, Ross E, Wolf GL, Quay SC (1988) Invest Radiol 23:S281–S285, Duewell S, Wüthrich R, von Schulthess GK, Jenny HB, Muller RN, Moerker T, Fuchs WA (1991) Invest Radiol 26:50–57, von Schulthess GK, Duewell S, Jenny H-B, Wüthrich R, Peter HH (1990) Invest Radiol 25:S48, Muetterties KA, Hoener B-A, Engelstad BL, Tongol JM, Wikstrom MG, Wang S-C, Eason RG, Moseley ME, White DL (1991) Magn Reson Med 22:88–100, White DL, Eason RG, Alkire AL, Price DC, Hoener BA, Milco LA, Keen RE, Barnhart JL (1991) Invest Radiol 26:S146–S147, Hoener B-A, Tzika AA, Englestad BL, White DL (1991) Magn Reson Med 17:509–515, Wesbey GE, Brasch RC, Engelstad BL, Moss AA, Crooks LE, Brito AC (1983) Radiology 149:175–180, Rubin DL, Muller HH, Young SW (1992) Magn Reson Med 23:154–165, Tart RP, Li KCP, Storm BL, Rolfes RJ, Ang PGP (1991) Magn Reson Imaging 9:559–568, Patten RM, Moss AA, Fenton TA, Elliott S (1992) Journal of Magnetic Resonance Imaging 2:25–34, Patten RM, Lo SK, Phillips JJ, Bowman SC, Glazer GM, Wall SD, Bova JG, Harris RD, Wheat RL, Johnson CD, Kressel HY, Stillman AE, Halvorsen RA, Moss AA (1993) Radiology 189:277–283, Kivelitz D, Gehl H-B, Heuck A, Krahe T, Taupitz M, Lodemann K-P, Hamm B (1999) Acta Radiol 40:429–435, Hirohashi S, Uchida H, Yoshikawa K, Fujita N, Ohtomo K, Yuasa Y, Kawamura Y, Matsui O (1994) Magn Reson Imaging 12:837–846, Malcolm PN, Brown JJ, Hahn PF, Stillman AE, Li KCP, Kawamura Y, Tanaka T, Noel JK, Molony BA, Johnson MF, Hildebolt CF (2000) Journal of Magnetic Resonance Imaging 12:702–707, Suto Y, Kamba M, Kato T (1995) Br J Radiol 68:1099–1102, Hirohashi S, Hirohashi R, Uchida H, Kitano S, Ono W, Ohishi H, Nakanishi S (1997) Radiology 203:281–285, Li KCP, Ang PGP, Tart RP, Storm BL, Rolfes R, Ho-Tai PCK (1990) Magn Reson Imaging 8:589–598, Kraus BB, Rappaport DC, Ros PR, Torres GM (1994) Magn Reson Imaging 12:847–858, Ogawa Y, Noda Y, Morio K, Nishioka A, Inomata T, Yoshida S, Toki T-I, Ogoshi S (1996) Journal of Computer Assisted Tomography 20:455–459, Unger EC, Fritz TA, Palestrant D, Meakem TJ, Granstrom P, Gatenby RA (1993) Journal of Magnetic Resonance Imaging 3:119–124, Aime S, Botta M, Fasano M, Terreno E (1993) Spectrochim Acta, Part A 49 A:1315–1322, Davies JA, Dutremez SG, Hockensmith CM, Keck R, Richardson N, Selman S, Smith DA, Ulmer CW, II, Wheatley LS, Zeiss J (1996) Academic Radiology 3:936–945, Tweedle MF (1997) European Radiology 7:S225–S230, Geraldes CFGC, Sherry AD, Brown RD, Koenig SH (1986) Magn Reson Med 3:242–250, Chang CA, Francesconi LC, Malley MF, Kumar K, Gougoutas JZ, Tweedle MF (1993) Inorg Chem 32:3501–3508, Yushmanov VE, Imasato H, Tominaga TT, Tabak M (1996) J Inorg Biochem 61:233–250, Balcom BJ, Fischer AE, Carpenter TA, Hall LD (1993) J Am Chem Soc 115:3300–3305, Gore JC, Kang YS, Schulz RJ (1984) Phys Med Biol 29:1189–1197, Vymazal J, Bulte JWM, Frank JA, di Chiro G, Brooks RA (1993) Journal of Magnetic Resonance Imaging 3:637–640, Fischer AE, Carpenter TA, Tyler JA, Hall LD (1995) Magn Reson Imaging 13:819–826, Potter K, Spencer RGS, McFarland EW (1997) Biochim Biophys Acta 1334:129–139, Fischer AE, Hall LD (1996) Magn Reson Imaging 14:779–783, Fischer AE, Balcom BJ, Fordham EJ, Carpenter TA, Hall LD (1995) J Phys D: Appl Phys 28:384–397, Fischer AE, Hall LD (1994) Mag Reson Mater Phys Biol Med 2:203–210, Päuser S, Keller K, Zschunke A, Mügge C (1993) Magn Reson Imaging 11:419–424, Tietze O, Reck G, Schulz B, Zschunke A, Keller K (1996) J Prakt Chem/Chem-Ztg 338:642–646, Kupka T, Dziegielewski JO, Pasterna G, Malecki JG (1992) Magn Reson Imaging 10:855–858, Bigham SL, Ballard JD, Giles KD, Clelland CS, Jeffcoat R, Griffin KS, Farley TD, Bushman DR, Wright JR (1990) Physiol Chem Phys Med NMR 22:63–72. 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